John Cain Arena is the proud home of Victoria's Super Netball teams, Melbourne Vixens and Collingwood Magpies.

Established in 2008 following the amalgamation of the Melbourne Phoenix and Melbourne Kestrels Netball Clubs, the Melbourne Vixens have long called the Arena home and have a proud history of success.

One of the Arena's newest home tenants, the Collingwood Magpies were founded in 2016, Since joining the league, the Magpies have enjoyed plenty of success, finishing in the top four in both the 2017 and 2019 seasons.

The Arena has also hosted international netball, with the Australian Diamonds having regularly featured, particularly against rivals the New Zealand Silver Ferns.